大剂量甲基强的松龙治疗严重急性横贯性脊髓炎
High dose methylprednisolone in severe acute transverse myelopathy.
作者信息
Sébire G, Hollenberg H, Meyer L, Huault G, Landrieu P, Tardieu M
机构信息
Department of Paediatrics, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
出版信息
Arch Dis Child. 1997 Feb;76(2):167-8. doi: 10.1136/adc.76.2.167.
No effective treatment has been shown for patients with acute transverse myelopathy. In an open study five children with severe acute transverse myelopathy were treated with intravenous methylprednisolone and compared with a historical group of 10 patients. The results show that in the methylprednisolone treatment group compared with the historical group of 10 patients: the median time to walk independently was significantly reduced (23 v 97 days); the proportion of patients with a full recovery within 12 months was significantly higher (80 v 10%); all patients had complete motor recovery within one year in contrast with only two of 10 patients in the historical group; and serious adverse effects did not occur. This pilot study suggests that high dose methylprednisolone is effective in the treatment of acute transverse myelopathy.
对于急性横贯性脊髓炎患者，尚未有有效的治疗方法被证实。在一项开放性研究中，对5名患有严重急性横贯性脊髓炎的儿童采用静脉注射甲基强的松龙进行治疗，并与一个由10名患者组成的历史对照组进行比较。结果显示，与10名患者的历史对照组相比，甲基强的松龙治疗组：独立行走的中位时间显著缩短（23天对97天）；12个月内完全康复的患者比例显著更高（80%对10%）；所有患者在一年内均实现了完全运动恢复，而历史对照组的10名患者中只有2名；且未发生严重不良反应。这项初步研究表明，高剂量甲基强的松龙对急性横贯性脊髓炎的治疗有效。
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