通过消化间期胃十二指肠测压法和血浆胃动素水平对运动障碍样消化不良进行进一步分类。

Further classification of dysmotility-like dyspepsia by interdigestive gastroduodenal manometry and plasma motilin level.

作者信息

Kusano M, Sekiguchi T, Kawamura O, Kikuchi K, Miyazaki M, Tsunoda T, Horikoshi T, Mori M

机构信息

First Department of Internal Medicine, School of Medicine, Gunma University, Japan.

出版信息

Am J Gastroenterol. 1997 Mar;92(3):481-4.

PMID:9068474

Abstract

OBJECTIVE

To investigate interdigestive gastroduodenal motility with an infused catheter and measure plasma motilin levels in eight normal individuals and 18 patients with dysmotility-like dyspepsia.

METHODS AND RESULTS

All normal individuals had normal gastroduodenal interdigestive migrating complexes. Patients with dysmotility-like dyspepsia were classified into three subgroups on the basis of gastric antral motility: 1) seven patients with normal interdigestive migrating complexes, 2) five patients without interdigestive migrating complexes and with gastric phase II predominant over phase I, and 3) six patients without interdigestive migrating complexes and with phase I predominance. The maximum and mean plasma motilin levels were significantly different in normal individuals from those in subgroup 3 (Kruskal-Wallis test, p < 0.05).

CONCLUSIONS

Dysmotility-like dyspepsia appears to be a heterogeneous condition. Abnormal motilin secretion may cause dysmotility in subgroup 3, but dyspepsia in subgroup 1 and the absence of interdigestive migrating complexes in subgroup 2 could not be explained only on this basis.

摘要

目的

使用灌注导管研究正常人和消化不良样消化不良患者的消化间期胃十二指肠动力，并测量血浆胃动素水平。18名消化不良样消化不良患者。

方法与结果

所有正常人的胃十二指肠消化间期移行性复合运动均正常。消化不良样消化不良患者根据胃窦动力分为三个亚组：1）7名消化间期移行性复合运动正常的患者；2）5名无消化间期移行性复合运动且胃Ⅱ期比Ⅰ期占优势的患者；3）6名无消化间期移行性复合运动且Ⅰ期占优势的患者。正常人与亚组3患者的血浆胃动素最高水平和平均水平有显著差异（Kruskal-Wallis检验，p<0.05）。