蛛网膜下腔出血的家族史：详细调查所有亲属的补充价值。
Family history of subarachnoid haemorrhage: supplemental value of scrutinizing all relatives.
作者信息
Greebe P, Bromberg J E, Rinkel G J, Algra A, van Gijn J
机构信息
University Department of Neurology, Utrecht, the Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 1997 Mar;62(3):273-5. doi: 10.1136/jnnp.62.3.273.
OBJECTIVE AND METHODS
To assess the validity of the family history obtained at the bedside of patients with recent subarachnoid haemorrhage by subsequently contacting all first and second degree relatives, with verification from medical record data.
RESULTS
In a prospectively collected series of 163 patients with recent subarachnoid haemorrhage the history or cause of death could be ascertained in 1259 (98%) of the first degree relatives and in 3038 (85%) of the second degree relatives. For first degree relatives only, the sensitivity of the family history at the bedside was 0.75 (95% confidence interval (95% CI) 0.35-0.97) and the positive predictive value was 0.55 (95% CI 0.23-0.83); for first and second degree relatives together the sensitivity was 0.58 (95% CI 0.28-0.85) and the positive predictive value was 0.64 (95% CI 0.31-0.89).
CONCLUSION
The accuracy of the family history taken at the bedside is modest; a more thorough collection of data is crucial if the decision is taken to screen relatives based on the family history.
目的与方法
通过随后联系所有一级和二级亲属并从病历数据进行核实，评估在近期蛛网膜下腔出血患者床边获取的家族史的有效性。
结果
在一个前瞻性收集的163例近期蛛网膜下腔出血患者系列中，1259名（98%）一级亲属和3038名（85%）二级亲属的病史或死因得以确定。仅对于一级亲属，床边家族史的敏感性为0.75（95%置信区间（95%CI）0.35 - 0.97），阳性预测值为0.55（95%CI 0.23 - 0.83）；对于一级和二级亲属合计，敏感性为0.58（95%CI 0.28 - 0.85），阳性预测值为0.64（95%CI 0.31 - 0.89）。
结论
床边获取的家族史准确性一般；如果决定根据家族史对亲属进行筛查，更全面地收集数据至关重要。
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