Arfaa F, Ghadirian E
Am J Trop Med Hyg. 1977 Sep;26(5 Pt 1):866-71. doi: 10.4269/ajtmh.1977.26.866.
In six villages near Isfahan in central Iran 1,455 persons were examined for intestinal parasites. Those with Ascaris infection were treated with pyrantel pamoate in a single dose of 10 mg/kg body weight and all stools passed during 48 hours after treatment were collected in plastic pans and screened for worms which were then sexed and measured. Ascaris infection rates, 87--95% in the six villages before treatment, were reduced to 1--8% (average 5%) and the mean number of eggs in the feces was reduced from 19/mg to less than 1/mg. All age groups and both sexes were about equally infected, and the average number of worms expelled by treatment ranged from 16 per infected person below 5 years of age to 31 per person 20--39 years of age. Mature and immature worms together were expelled from persons treated at all seasons, indicating that worms were acquired and lost continuously throughout the year. Fecal examination at 2, 4, 6, and 12 months after treatment showed that the prevalence at 12 months had returned to the original level (87% vs. 91%) but the average intensity as reflected in egg-counts had not (10 vs. 19/mg feces). The findings confirm the necessity of repeated treatment at 2- to 3-month intervals.
在伊朗中部伊斯法罕附近的六个村庄，对1455人进行了肠道寄生虫检查。对感染蛔虫的人用噻嘧啶双羟萘酸盐进行治疗，单次剂量为10毫克/千克体重，治疗后48小时内排出的所有粪便收集在塑料盘中，筛查其中的蠕虫，然后对蠕虫进行性别鉴定和测量。治疗前，这六个村庄的蛔虫感染率为87%-95%，治疗后降至1%-8%（平均5%），粪便中虫卵的平均数量从19个/毫克降至不足1个/毫克。所有年龄组和男女感染情况大致相同，治疗后排出的蠕虫平均数量从5岁以下感染人群每人16条到20-39岁人群每人31条不等。在所有季节接受治疗的人都排出了成熟和未成熟的蠕虫，这表明蠕虫在一年中持续感染和排出。治疗后2个月、4个月、6个月和12个月的粪便检查显示，12个月时的患病率已恢复到原来的水平（87%对91%），但虫卵计数反映的平均感染强度未恢复（10个/毫克粪便对19个/毫克粪便）。这些发现证实了每隔2至3个月重复治疗的必要性。
