Brevetti G, Perna S, Sabba C, Martone V D, Di Iorio A, Barletta G
Department of Medicine, University Federico II, Naples, Italy.
Am J Cardiol. 1997 Mar 15;79(6):777-80. doi: 10.1016/s0002-9149(96)00867-3.
A double-blind, dose titration study was designed to assess the efficacy of propionyl-L-carnitine in intermittent claudication. The effect on walking capacity was described in a previous article. This study reports on the effect on quality of life, assessed by the McMaster Health Index Questionnaire (MHIQ). After 24 weeks of treatment, the global MHIQ score did not show any difference from baseline in patients randomized to placebo (n = 102). Conversely, it increased from 0.59 +/- 0.12 to 0.64 +/- 0.12 in those taking propionyl-L-carnitine (n = 85). Analysis of variance showed a significant difference between treatments (p = 0.018). Stepwise multiple regression analysis identified baseline maximal walking capacity (cutoff point 250 m) as a predictor of treatment outcome. In patients walking < 250 m, propionyl-L-carnitine significantly improved physical function (p = 0.027), emotional function (p = 0.002), and global MHIQ score (p = 0.002) compared with placebo. Also, for maximal walking capacity, group difference significantly favored propionyl-L-carnitine (p = 0.009). In patients with baseline maximal walking capacity > or = 250 m, propionyl-L-carnitine did not affect the MHIQ scores, nor improve walking performance. These data indicate that propionyl-L-carnitine exerts beneficial effects on quality of life and walking performance in patients with more severely limited walking capacity.
一项双盲、剂量滴定研究旨在评估丙酰-L-肉碱治疗间歇性跛行的疗效。之前的一篇文章描述了其对步行能力的影响。本研究报告了通过麦克马斯特健康指数问卷（MHIQ）评估的对生活质量的影响。治疗24周后，随机分配到安慰剂组的患者（n = 102）的MHIQ总体评分与基线相比无差异。相反，服用丙酰-L-肉碱的患者（n = 85）的评分从0.59±0.12提高到了0.64±0.12。方差分析显示治疗组间存在显著差异（p = 0.018）。逐步多元回归分析确定基线最大步行能力（临界点250米）为治疗结果的预测指标。在最大步行距离小于250米的患者中，与安慰剂相比，丙酰-L-肉碱显著改善了身体功能（p = 0.027）、情绪功能（p = 0.002）和MHIQ总体评分（p = 0.002）。此外，对于最大步行能力，组间差异显著有利于丙酰-L-肉碱（p = 0.009）。在基线最大步行能力≥250米的患者中，丙酰-L-肉碱未影响MHIQ评分，也未改善步行表现。这些数据表明，丙酰-L-肉碱对步行能力严重受限的患者的生活质量和步行表现具有有益作用。
