Bradley S J, Taylor M J, Rovet J F, Goldberg E, Hood J, Wachsmuth R, Azcue M P, Pencharz P B
Hospital for Sick Children, Toronto, Canada.
J Clin Exp Neuropsychol. 1997 Feb;19(1):20-33. doi: 10.1080/01688639708403833.
This study assessed brain function in 20 adolescent females with anorexia nervosa (AN) and 20 controls using event-related potentials (ERPs) and a battery of neuropsychological tests. In the AN group, N4 latencies for a nonverbal memory task were significantly longer than for a verbal task, and P3 latencies for the verbal task were significantly longer among anorexics as compared to controls. On the nonverbal task, the AN group failed to show a right > left hemispheric asymmetry for P3 amplitudes which was observed for controls. These group differences for P3 latency and amplitude were particularly pronounced in the central-parietal region of the head. Body Mass Index (BMI) in the anorexic group significantly predicted N4 amplitudes for the verbal task in the left hemisphere and P3 amplitudes for the nonverbal task in the right hemisphere. The two groups did not differ on any of the tests used to assess neuropsychological functioning. Eight nutritionally recovered patients and their matched controls were retested using the same procedures. Anorexics showed larger P3 amplitudes for the verbal as compared to the nonverbal task at follow-up. These findings provide evidence for localized brain dysfunction in anorexia nervosa that only partially normalizes with weight gain.
本研究使用事件相关电位（ERP）和一系列神经心理学测试，对20名患有神经性厌食症（AN）的青春期女性和20名对照者的脑功能进行了评估。在AN组中，非言语记忆任务的N4潜伏期显著长于言语任务，并且与对照组相比，厌食症患者言语任务的P3潜伏期显著更长。在非言语任务中，AN组未表现出对照组所观察到的P3波幅右半球大于左半球的不对称性。P3潜伏期和波幅的这些组间差异在头部的中央顶叶区域尤为明显。厌食症组的体重指数（BMI）显著预测了左半球言语任务的N4波幅以及右半球非言语任务的P3波幅。两组在用于评估神经心理功能的任何测试中均无差异。使用相同程序对8名营养恢复的患者及其匹配的对照者进行了重新测试。在随访时，厌食症患者在言语任务中表现出比非言语任务更大的P3波幅。这些发现为神经性厌食症中局部脑功能障碍提供了证据，这种功能障碍仅随着体重增加而部分恢复正常。
