性甾体激素对豚鼠离体回肠对乙酰胆碱和组胺反应的抑制作用。
Inhibitory effects of sexual steroidal hormones on the responses of the isolated guinea-pig lleum to acetylcholine and histamine.
作者信息
Seaman I, Famaey J P, Fontaine J, Reuse J
出版信息
Arch Int Pharmacodyn Ther. 1977 Jun;227(2):233-7.
Six sexual steroidal hormones (progesterone, pregnenolone, testosterone, ethinyl-oestradiol, oestriol and oestrone) inhibit acetylcholine- and histamine-induced contractions of the isolated guinea-pig ileum. Different degrees of inhibitory capacity were found. High concentrations of PGE1 and F2alpha reverse some of these inhibitions. This reversal seems to be non-specific and probably related to sensitization of the ileal smooth muscle by prostaglandins. The inhibitory action of sexual steroids might be non-specific as well. But a "corticoid-like" effect cannot be excluded.
六种性甾体激素（孕酮、孕烯醇酮、睾酮、炔雌醇、雌三醇和雌酮）可抑制乙酰胆碱和组胺诱导的豚鼠离体回肠收缩。发现它们具有不同程度的抑制能力。高浓度的前列腺素E1和F2α可部分逆转这些抑制作用。这种逆转似乎是非特异性的，可能与前列腺素使回肠平滑肌致敏有关。性甾体激素的抑制作用也可能是非特异性的。但不能排除“类皮质激素样”效应。
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