Holloway A F, Stennard F A, West A K
Division of Biochemistry, University of Tasmania, Australia.
FEBS Lett. 1997 Mar 3;404(1):41-4. doi: 10.1016/s0014-5793(97)00082-3.
A human MT gene from the functional locus on chromosome 16, MT1L, is characterised and shown to produce mRNA in at least four human tissues. This gene is unlikely to produce a metallothionein protein because it contains a termination codon at position 26, by analogy to other human MT1 genes. MT1L cDNA is almost identical to another metallothionein cDNA clone reported recently, MT1R, suggesting that either there are unmapped human metallothionein genes, or that MT1L is polymorphic.
对位于16号染色体功能位点上的人类金属硫蛋白（MT）基因MT1L进行了表征，结果表明它至少在四种人体组织中产生信使核糖核酸（mRNA）。由于该基因在第26位含有一个终止密码子，与其他人类MT1基因类似，所以它不太可能产生金属硫蛋白。MT1L互补脱氧核糖核酸（cDNA）与最近报道的另一个金属硫蛋白cDNA克隆MT1R几乎完全相同，这表明要么存在未定位的人类金属硫蛋白基因，要么MT1L具有多态性。
