Marrion N V
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.
Annu Rev Physiol. 1997;59:483-504. doi: 10.1146/annurev.physiol.59.1.483.
M-current is a non-inactivating potassium current found in many neuronal cell types. In each cell type, it is dominant in controlling membrane excitability by being the only sustained current in the range of action potential initiation. It can be modulated by a large array of receptor types, and the modulation can occur either by suppression or enhancement. Modulation of M-current has dramatic effects on neuronal excitability. This review discusses the numerous second messenger pathways that converge on regulation of this current: in particular, two forms of regulation of the M-current, receptor-mediated modulation and the control of macroscopic current amplitude by intracellular calcium. Both types of regulation are discussed with reference to the modulation of single-channel gating properties.
M电流是在许多神经元细胞类型中发现的一种非失活钾电流。在每种细胞类型中，它通过作为动作电位起始范围内唯一的持续电流，在控制膜兴奋性方面起主导作用。它可被大量受体类型调节，调节可通过抑制或增强发生。M电流的调节对神经元兴奋性有显著影响。本综述讨论了汇聚于该电流调节的众多第二信使途径：特别是，M电流的两种调节形式，受体介导的调节和细胞内钙对宏观电流幅度的控制。两种调节类型均结合单通道门控特性的调节进行讨论。
