Jungersten L, Ambring A, Wall B, Wennmalm A
Department of Clinical Physiology, Göteborg University, Sahlgrenska University Hospital, Sweden.
J Appl Physiol (1985). 1997 Mar;82(3):760-4. doi: 10.1152/jappl.1997.82.3.760.
We analyzed nitrate, a major stable end product of nitric oxide (NO) metabolism in vivo in plasma and urine from groups of healthy subjects with different working capacities. Resting plasma nitrate was higher in athletic subjects than in nonathletic controls [45 +/- 2 vs. 34 +/- 2 (SE) microM; P < 0.01]. In other subjects, both the resting plasma nitrate level (r = 0.53; P < 0.01) and the urinary excretion of nitrate at rest (r = 0.46; P < 0.01) correlated to the subjects' peak work rates, as determined by bicycle ergometry. Two hours of physical exercise elevated plasma nitrate by 18 +/- 4 (P < 0.01) and 16 +/- 6% (P < 0.01), respectively, in athletes and nonathletes, compared with resting nitrate before exercise. We conclude that physical fitness and formation of NO at rest are positively linked to each other. Furthermore, a single session of exercise elicits an acute elevation of NO formation. The observed positive relation between physical exercise and NO formation may help to explain the beneficial effects of physical exercise on cardiovascular health.
我们分析了硝酸盐，它是一氧化氮（NO）在体内代谢的一种主要稳定终产物，来自不同工作能力的健康受试者组的血浆和尿液中的硝酸盐。运动受试者静息血浆硝酸盐水平高于非运动对照组[45±2对34±2（SE）微摩尔；P<0.01]。在其他受试者中，静息血浆硝酸盐水平（r = 0.53；P<0.01）和静息时尿硝酸盐排泄量（r = 0.46；P<0.01）均与受试者的峰值工作率相关，峰值工作率通过自行车测力计测定。与运动前的静息硝酸盐相比，两小时的体育锻炼使运动员和非运动员的血浆硝酸盐分别升高了18±4（P<0.01）和16±6%（P<0.01）。我们得出结论，身体素质与静息时NO的形成呈正相关。此外，单次运动可引起NO形成的急性升高。观察到的体育锻炼与NO形成之间的正相关关系可能有助于解释体育锻炼对心血管健康的有益作用。
