Schnyder U W, Gloor M, Taugner M
Berufsdermatosen. 1977;25(3):101-7.
In individuals free from skin diseases, the resistance and the neutralisation to alkali, and the quantity of lipids at the surface of the skin, are constitltional factors; these idiotypically (genetically) controlled factors are subject to paratypical (environmental) variations. The frequency of a reduced alkali neutralisation and of sebostasis in case of neurodermitis atopica and of ichthyosis vulgaris is not dealt with in the literature, but it results from literature findings that a pathologic alkali resistance is a facultative feature in neurodermitis atopica, while it is an obligatory one in ichthyosis vulgaris. The difference seems to be conditioned genetically. In neurodermitis atopica, the genotype is in itself of no pathogenic importance since the disease is induced exclusively by exogenous and endogenous, non hereditary agents. In ichthyosis vulgaris, the reduced alkali resistance falls into the pleiotropic character of the disease.
在无皮肤疾病的个体中，皮肤对碱的抵抗力和中和能力以及皮肤表面脂质的数量是体质因素；这些由独特型（遗传）控制的因素会受到副型（环境）变化的影响。关于在寻常型神经性皮炎和寻常性鱼鳞病中碱中和能力降低和皮脂分泌停滞的频率，文献中并未涉及，但从文献研究结果可知，病理性的耐碱性在寻常型神经性皮炎中是一种兼性特征，而在寻常性鱼鳞病中则是一种必然特征。这种差异似乎是由遗传决定的。在寻常型神经性皮炎中，基因型本身并无致病重要性，因为该疾病完全由外源性和内源性非遗传性因素诱发。在寻常性鱼鳞病中，耐碱性降低属于该疾病的多效性特征。
