经刺激的小鼠腹腔巨噬细胞对维生素B₁₂转运蛋白——转钴胺素II的合成。
The synthesis of transcobalamin II, a vitamin B12 transport protein, by stimulated mouse peritoneal macrophages.
作者信息
Rachmilewitz B, Rachmilewitz M, Chaouat M, Schlesinger M
出版信息
Biomedicine. 1977 Jul;27(6):213-4.
PMID:907799
Abstract
The concentration of transcobalamin II (TCII), the vitamin B12 binding protein which delivers vitamin B12 to the tissues, was determined in stimulated and non stimulated mouse peritoneal exudate cells (PEC). Following a single intraperitoneal thioglycollate injection there was a marked increase in TCII which was shown to be produced by the adherent cells of the PEC i.e. the macrophages. It has been concluded that the PEC macrophages synthesize TCII.
摘要
测定了转钴胺素II（TCII）的浓度，TCII是一种将维生素B12输送到组织的维生素B12结合蛋白，在刺激和未刺激的小鼠腹腔渗出细胞（PEC）中进行了此项测定。单次腹腔注射巯基乙酸盐后，TCII显著增加，结果表明其由PEC的贴壁细胞即巨噬细胞产生。得出的结论是，PEC巨噬细胞合成TCII。
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