Khrustalev S A, Khar'kovskaia N A, Vasil'eva N N
Biull Eksp Biol Med. 1977 Aug;84(8):200-2.
Mongrel guinea pigs were given 3-indolilacrilacid and 2-aminoacetophenon derivates of tryptophan which blastomogenic action was previously revealed in experiments on inbred mice. Both substances produced tumors in animals of the experimental groups earlier than in the control group, this fact showing both the preparations to have blastomogenic effect. The results of the investigation show the possibility of using guinea pigs for studying the blastomogenic action of weak cancerogenic agents to which the endogenic blastomogenic substances belong.
给杂种豚鼠注射色氨酸的3 - 吲哚丙烯酸和2 - 氨基苯乙酮衍生物，这些物质在对近交系小鼠的实验中先前已显示出致瘤作用。两种物质在实验组动物中产生肿瘤的时间都比对照组早，这一事实表明这两种制剂都具有致瘤作用。研究结果表明，豚鼠可用于研究内源性致瘤物质所属的弱致癌剂的致瘤作用。
