Tew S, Jamieson G G, Pilowsky I, Myers J
Department of Surgery, Royal Adelaide Hospital, South Australia.
Dis Esophagus. 1997 Jan;10(1):9-15. doi: 10.1093/dote/10.1.9.
The aim of this study was to determine if patients who experience heartburn but have no objective evidence of gastroesophageal reflux disease are responding appropriately to their symptoms. One hundred and forty patients who had been referred for investigations of heartburn (75 males, 65 females, mean age 48 years) answered an Illness Behavior Questionnaire. All patients underwent pH monitoring tests, and endoscopy results were obtained for 119 patients. There was objective evidence of reflux disease on endoscopy or pH monitoring in 105 patients and no objective evidence of reflux in 35 patients. Sixty-six patients were endoscopy-'positive' while 53 patients were endoscopy-'negative'. The Illness Behavior Questionnaires for the four groups were analysed for seven scales of illness behavior and these were compared with reference populations. Patients with heartburn but no objective reflux were similar to those with heartburn and objective reflux on all scales of the Illness Behavior Questionnaire. The reflux group without endoscopic esophagitis also responded to their symptoms in the same way as those with endoscopic esophagitis. It is concluded that a patient's perception of symptoms in gastroesophageal reflux is probably not related to the degree of esophageal mucosal damage.
本研究的目的是确定有烧心症状但无胃食管反流病客观证据的患者对其症状的反应是否恰当。140例因烧心接受检查的患者（75例男性，65例女性，平均年龄48岁）回答了一份疾病行为问卷。所有患者均接受了pH监测测试，并获得了119例患者的内镜检查结果。105例患者在内镜检查或pH监测中有反流病的客观证据，35例患者无反流的客观证据。66例患者内镜检查“阳性”，53例患者内镜检查“阴性”。对四组患者的疾病行为问卷进行了七种疾病行为量表分析，并与参考人群进行了比较。在疾病行为问卷的所有量表上，有烧心但无客观反流的患者与有烧心且有客观反流的患者相似。无内镜食管炎的反流组对症状的反应与有内镜食管炎的患者相同。结论是，患者对胃食管反流症状的感知可能与食管黏膜损伤程度无关。
