Fang A, Pierson D L, Mishra S K, Koenig D W, Demain A L
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
J Ind Microbiol Biotechnol. 1997 Jan;18(1):22-5. doi: 10.1038/sj.jim.2900345.
Rotating bioreactors designed at NASA's Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was beta-lactam antibiotic production by Streptomyces clavuligerus. Both growth and beta-lactam production occurred in simulated microgravity. Stimulatory effects of phosphate and L-lysine, previously detected in normal gravity, also occurred in simulated microgravity. The degree of beta-lactam antibiotic production was markedly inhibited by simulated microgravity.
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