作为药物靶点的DNA促旋酶
DNA gyrase as a drug target.
作者信息
Maxwell A
机构信息
Dept of Biochemistry, University of Leicester, UK.
出版信息
Trends Microbiol. 1997 Mar;5(3):102-9. doi: 10.1016/S0966-842X(96)10085-8.
PMID:9080608
Abstract
DNA gyrase is a remarkable enzyme, catalysing the seemingly complex reaction of DNA supercoiling. As gyrase is essential in prokaryotes, it is a good target for antibacterial agents. These agents have diverse chemical structures and interact with gyrase in a variety of ways.
摘要
DNA 回旋酶是一种非凡的酶，催化看似复杂的 DNA 超螺旋反应。由于回旋酶在原核生物中至关重要，它是抗菌剂的良好靶点。这些抗菌剂具有多样的化学结构，并以多种方式与回旋酶相互作用。
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