脂蛋白对细胞培养中3T3-L1和人前脂肪细胞分化的影响。
Effect of lipoproteins on the differentiation of 3T3-L1 and human preadipocytes in cell culture.
作者信息
Stanton L A, van de Venter M, Litthauer D, Oelofsen W
机构信息
Department of Biochemistry, University of Port Elizabeth, South Africa.
出版信息
Comp Biochem Physiol B Biochem Mol Biol. 1997 Jan;116(1):65-73. doi: 10.1016/s0305-0491(96)00151-4.
High-density and low-density lipoprotein (LDL) stimulated 3T3-L1 and human preadipocyte differentiation in vitro. In both cell types, LDL exhibited the greatest stimulatory effect. LDL suppressed the development of catecholamine-stimulated lipolysis in differentiating 3T3-L1 and human preadipocytes when present during preadipocyte proliferation and early stages of differentiation. The effect of lipoproteins on development of human preadipocyte (but not 3T3-L1) lipolysis may involve beta-adrenoceptors.
高密度脂蛋白和低密度脂蛋白（LDL）在体外刺激3T3-L1细胞和人前脂肪细胞分化。在这两种细胞类型中，LDL表现出最大的刺激作用。当在脂肪前体细胞增殖和分化早期存在时，LDL抑制分化中的3T3-L1细胞和人脂肪前体细胞中儿茶酚胺刺激的脂肪分解的发展。脂蛋白对人脂肪前体细胞（而非3T3-L1细胞）脂肪分解发展的影响可能涉及β-肾上腺素能受体。
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