Paul S, Bezbaruah R L, Roy M K, Ghosh A C
Division of Biochemistry, Regional Research Laboratory, Jorhat, Assam, India.
Lett Appl Microbiol. 1997 Mar;24(3):169-71. doi: 10.1046/j.1472-765x.1997.00364.x.
The MAR indexes of hospital isolates of Pseudomonas aeruginosa were determined with reference to nine different cephalosporins. The values for all the strains were higher than 0.2 suggesting their origin from a high risk source of contamination where antibiotics are often used. Emergence of MAR pathogenic strains of Ps. aeruginosa indicated possible nosocomial infection in the hospital environment. beta-Lactamases produced by these organisms were tested and their inhibition by clavulanic acid was studied. beta-Lactamase produced by one of these strains (Ps-1) could not be inhibited by clavulanic acid whereas beta-lactamases of three other strains (Ps-2, Ps-3 and Ps-4) could be inhibited by clavulanic acid in the presence of cephalosporins, suggesting a possible use of clavulanic acid in combination with cephalosporins, to combat beta-lactamase induced resistance in Ps. aeruginosa.
参照九种不同的头孢菌素测定了医院分离的铜绿假单胞菌的多重耐药（MAR）指数。所有菌株的值均高于0.2，表明它们源自抗生素经常使用的高风险污染源。铜绿假单胞菌多重耐药致病菌株的出现表明医院环境中可能存在医院感染。对这些菌株产生的β-内酰胺酶进行了检测，并研究了克拉维酸对其的抑制作用。其中一株菌株（Ps-1）产生的β-内酰胺酶不能被克拉维酸抑制，而其他三株菌株（Ps-2、Ps-3和Ps-4）的β-内酰胺酶在头孢菌素存在的情况下可被克拉维酸抑制，这表明克拉维酸可能与头孢菌素联合使用，以对抗铜绿假单胞菌中β-内酰胺酶诱导的耐药性。
