Lee P A, O'Leary L A, Songer N J, Coughlin M T, Bellinger M F, LaPorte R E
Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pa, USA.
Arch Pediatr Adolesc Med. 1997 Mar;151(3):260-3. doi: 10.1001/archpedi.1997.02170400046008.
To compare paternity among men with former bilateral cryptorchidism (referred to as the bilateral group) with a group of men with former unilateral cryptorchidism (referred to as the unilateral group) and a control group.
Epidemiologic survey of study cohort.
Large urban pediatric hospital.
Men with former bilateral and unilateral cryptorchidism who underwent orchiopexy between 1955 and 1971 at the Children's Hospital of Pittsburgh, Pittsburgh, Pa, and a group of control men have been surveyed by questionnaire concerning paternity and factors related to paternity.
Paternity.
Among the married men who had bilateral cryptorchidism, 50% had fathered children, compared with 76% in the control group and 74% in the unilateral group. Data were similar when the men who were cohabitating were included with the married men. When men who had married and had attempted paternity were evaluated, 62% of the men in the bilateral group had been able to father children compared with 94% of the control group and 89% of the men in the unilateral group. No relationship was noted between the age of orchiopexy or lifestyle factors and paternity. Paternity among all groups was related to female-related infertility factors and to the presence of varicoceles.
Paternity was compromised after bilateral cryptorchidism when compared with men with former unilateral cryptorchidism and a control group. Among the bilateral group, infertility is about 3.5 times as frequent than the unilateral group and more than 6 times as frequent among the control group. No correlation was found between age of orchiopexy and paternity for either group.
比较曾患双侧隐睾症的男性（称为双侧组）与曾患单侧隐睾症的男性组（称为单侧组）以及对照组之间的生育情况。
对研究队列进行流行病学调查。
大型城市儿童医院。
1955年至1971年期间在宾夕法尼亚州匹兹堡市儿童医院接受睾丸固定术的曾患双侧和单侧隐睾症的男性，以及一组对照男性，通过问卷调查了他们的生育情况及与生育相关的因素。
生育情况。
在已婚的曾患双侧隐睾症的男性中，50%育有子女，而对照组这一比例为76%，单侧组为74%。将同居男性与已婚男性一同纳入分析时，数据相似。在对已婚且曾尝试生育的男性进行评估时，双侧组中62%的男性能够生育子女，而对照组为94%，单侧组为89%。未发现睾丸固定术年龄或生活方式因素与生育情况之间存在关联。所有组的生育情况均与女性相关的不孕因素以及精索静脉曲张的存在有关。
与曾患单侧隐睾症的男性和对照组相比，双侧隐睾症后生育能力受到影响。在双侧组中，不育的发生率约为单侧组的3.5倍，是对照组的6倍多。两组中均未发现睾丸固定术年龄与生育情况之间存在相关性。
