Cytogenetics and molecular genetics in multiple myeloma.
作者信息
Feinman R, Sawyer J, Hardin J, Tricot G
机构信息
Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.
出版信息
Hematol Oncol Clin North Am. 1997 Feb;11(1):1-25. doi: 10.1016/s0889-8588(05)70412-3.
PMID:9081201
Abstract
Specific cytogenetic abnormalities have been identified in multiple myeloma that confer a poor prognosis, even with intensive chemotherapy and autotransplants. The identification and characterization of potential genes involved in these different chromosomal changes and their interplay with oncogenes and tumor suppressor genes controlling cellular growth and apoptosis is the major focus of this review.
摘要
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