Al-Agidi S K, Papiha S S, Roberts D F
Clin Exp Immunol. 1977 Aug;29(2):247-55.
In a study of immunoglobulin levels in 192 apparently healthy individuals in Iraq, regional differences occur in IgE and IgG. The main levels of IgG, IgM and IgA tend to be low, and of IgE clearly elevated. It is suggested that this pattern may be explained by the presence of intestinal parasites which stimulate IgE production. The genetic differences that exist between the regional populations, and the occurrence of associations of immunoglobulin level with several polymorphic systems, suggests the possibility of a genetic element in the regional immunoglobulin differences.
在一项针对伊拉克192名看似健康个体的免疫球蛋白水平研究中,IgE和IgG存在区域差异。IgG、IgM和IgA的主要水平往往较低,而IgE明显升高。有人认为,这种模式可能是由刺激IgE产生的肠道寄生虫的存在所解释。区域人群之间存在的基因差异,以及免疫球蛋白水平与多个多态性系统的关联出现,表明区域免疫球蛋白差异中存在遗传因素的可能性。