双胞胎母亲患乳腺癌的风险。
Breast cancer risk in mothers of twins.
作者信息
Murphy M F, Broeders M J, Carpenter L M, Gunnarskog J, Leon D A
机构信息
ICRF General Practice Research Group, Radcliffe Infirmary, Oxford, UK.
出版信息
Br J Cancer. 1997;75(7):1066-8. doi: 10.1038/bjc.1997.181.
The risk of breast cancer associated with delivering a twin birth was examined in a population-based nested case-control study of nearly 4800 Swedish women with breast cancer and 47000 age-matched control subjects. All were aged less than 50 years and parous. After adjustment for age at first birth and parity, a 29% reduction in breast cancer risk was observed in mothers of twins relative to those who were not (odds ratio = 0.71, 95% confidence interval 0.55-0.91). These results provide evidence that women who bear twins are at reduced risk of breast cancer, one explanation for which may be their unusual levels of hormonal exposure.
在一项基于人群的巢式病例对照研究中，研究人员对近4800名患乳腺癌的瑞典女性和47000名年龄匹配的对照对象进行了调查，以探究双胎分娩与患乳腺癌风险之间的关系。所有研究对象年龄均小于50岁且已生育。在对首次生育年龄和产次进行调整后，与未生育双胞胎的母亲相比，生育双胞胎的母亲患乳腺癌的风险降低了29%（比值比=0.71，95%置信区间0.55-0.91）。这些结果表明，生育双胞胎的女性患乳腺癌的风险较低，其中一个原因可能是她们的激素暴露水平异常。
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