实验性肝硬化发展过程中总糖胺聚糖和特异性糖胺聚糖的合成
The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis.
作者信息
Gressner A M, Pazen H, Greiling H
出版信息
Experientia. 1977 Oct 15;33(10):1290-2. doi: 10.1007/BF01920139.
PMID:908398
Abstract
During hepatic fibrogenesis induced by long-term administration of thioacetamide, the synthesis of chondroitin 4,6-sulfate and hyaluronic acid was strongly enhanced; the formation of heparan sulfate comprising at least 70% of total liver GAG synthesis and of a keratan-sulfate-like fraction was stimulated 1.7 fold. Formation of dermatan-sulfate in liver could not be detected.
摘要
在长期给予硫代乙酰胺诱导的肝纤维化过程中，硫酸软骨素4,6 - 硫酸酯和透明质酸的合成显著增强；硫酸乙酰肝素的形成（占肝脏总糖胺聚糖合成的至少70%）以及类硫酸角质素部分的形成被刺激了1.7倍。在肝脏中未检测到硫酸皮肤素的形成。
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