Cra与通过代谢途径对碳通量的控制。
Cra and the control of carbon flux via metabolic pathways.
作者信息
Ramseier T M
机构信息
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
出版信息
Res Microbiol. 1996 Jul-Sep;147(6-7):489-93. doi: 10.1016/0923-2508(96)84003-4.
The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Doudoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cyclic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.
分解代谢物阻遏激活蛋白（Cra）控制肠道细菌代谢途径中碳流的方向。Cra与靶基因的控制区域结合，对编码糖酵解和恩特纳-杜德洛夫酶的基因表达产生负面影响，而对编码三羧酸循环、乙醛酸循环支路和糖异生酶的基因产生正面影响。Cra介导对Cra正向调控基因的不依赖环磷酸腺苷的分解代谢物阻遏以及对Cra负向控制基因的分解代谢物激活。
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