Ghent C N, Bloomer J R, Klatskin G
Gastroenterology. 1977 Nov;73(5):1125-30.
To define the relationship of bile acid retention to the pruritus of cholestasis, we quantified individual bile acids in serum, acetone swabs of skin, and skin tissue in 13 patients with cholestasis undergoing laparotomy and in 8 controls. There was no consistent relationship between pruritus and concentrations of either total or individual bile acids in serum. Skin tissue concentrations of bile acids were elevated in patients with cholestasis, were linearly related to serum levels, and did not differentiate between those patients with and those without pruritus. Concentrations of bile acids on the skin surface, which were lower than those reported by others, did not correlate with pruritus, and were decreased by simple soap and water washing. These data indicate that the pruritus of cholestasis is not directly related to the skin tissue concentration of any of the major bile acids, although a relationship to a particular molecular form of bile acids could not be excluded.
为明确胆汁酸潴留与胆汁淤积性瘙痒之间的关系，我们对13例接受剖腹手术的胆汁淤积患者及8例对照者的血清、皮肤丙酮拭子和皮肤组织中的单个胆汁酸进行了定量分析。瘙痒与血清中总胆汁酸或单个胆汁酸的浓度之间没有一致的关系。胆汁淤积患者皮肤组织中的胆汁酸浓度升高，与血清水平呈线性相关，且无法区分有瘙痒和无瘙痒的患者。皮肤表面的胆汁酸浓度低于其他人报告的浓度，与瘙痒无关，且通过简单的肥皂水洗浴即可降低。这些数据表明，胆汁淤积性瘙痒与任何主要胆汁酸的皮肤组织浓度无直接关系，尽管不能排除与特定分子形式的胆汁酸存在关联。
