Malaguarnera M, Di Fazio I, Romeo M A, Restuccia S, Laurino A, Trovato B A
Department of Internal Medicine and Geriatrics, University of Catania, Italy.
J Gastroenterol. 1997 Apr;32(2):211-5. doi: 10.1007/BF02936370.
Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P < 0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virus-induced inflammatory state.
白细胞介素6（IL-6）是一种由多种淋巴组织和非淋巴组织产生的多效性细胞因子。我们研究了IL-6与肝脏之间的关系，试图阐明这种细胞因子在丙型肝炎诱导的肝脏炎症中的作用。我们调查了25例慢性丙型肝炎患者（根据严重程度分为三组）和27名健康对照者血清IL-6的情况。我们的结果显示，慢性丙型肝炎患者的血清IL-6水平显著升高（P < 0.0001），与组织学活动指数（HAI）及其血清HCV-RNA水平相关。这种升高可能代表丙型肝炎病毒诱导的炎症状态的表达。
