Mégraud F
Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux, France.
J Gastroenterol. 1997 Apr;32(2):278-81. doi: 10.1007/BF02936383.
Helicobacter pylori has been shown to possess a very heterogeneous genoma despite its common phenotypic properties. Some characteristics relevant to pathogenesis have also been found to be heterogeneous. This is the case for adherence properties and the amount of urease produced, but it was not possible to relate these properties to disease entities. A vacuolating cytotoxin which alters epithelial cells has been found in about 60% of strains isolated from patients with ulcers versus 30% from those with gastritis only. The cagA gene can be used as a marker to detect the cag pathogenicity island. This DNA fragment seems to induce an increased inflammation in the gastric tissue via release of interleukin 8 by the epithelial cells. The association of this marker is strongly linked with ulcers compared with gastritis only (80% vs 55%, respectively). A number of other properties may be heterogeneous, but the low number of strains studied does not allow conclusions to be drawn.
尽管幽门螺杆菌具有共同的表型特征，但其基因组已被证明具有很大的异质性。一些与发病机制相关的特征也被发现具有异质性。粘附特性和脲酶产生量就是这种情况，但无法将这些特性与疾病实体联系起来。在从溃疡患者中分离出的约60%的菌株中发现了一种可改变上皮细胞的空泡毒素，而仅患有胃炎患者的菌株中这一比例为30%。cagA基因可作为检测cag致病岛的标志物。该DNA片段似乎通过上皮细胞释放白细胞介素8，在胃组织中引发炎症增加。与仅患胃炎相比，该标志物与溃疡的关联更为密切（分别为80%和55%）。许多其他特性可能也具有异质性，但所研究的菌株数量较少，无法得出结论。
