Nijenhuis L E
Hum Genet. 1977 Sep 22;38(2):175-82. doi: 10.1007/BF00527400.
A statistical method has been developed which can be used to distinguish between various possible explanations for the associations that have been observed between HLA and certain diseases. By analyzing the numbers of B27 positives with and without a second detectable B locus antigen in patients with ankylosing spondylitis and in a control series, three possible hypotheses have been tested: 1. the B27 antigen itself makes an individual more susceptible; 2. a recessive susceptibility gene is closely linked with HLA; 3. a dominant susceptibility gene is closely linked with HLA. In four groups of patients suffering from another disease the procedure has also been applied and it turns out that at least in some of these the second hypothesis can be rejected while the third seems to be the most likely.
已开发出一种统计方法，可用于区分对观察到的HLA与某些疾病之间关联的各种可能解释。通过分析强直性脊柱炎患者和对照组中存在和不存在第二种可检测到的B位点抗原的B27阳性个体数量，对三种可能的假设进行了检验：1. B27抗原本身使个体更易患病；2. 隐性易感基因与HLA紧密连锁；3. 显性易感基因与HLA紧密连锁。在四组患有其他疾病的患者中也应用了该方法，结果表明至少在其中一些患者中可以排除第二种假设，而第三种假设似乎最有可能。
