van den Berg-Loonen E M, Dekker-Saeys B J, Meuwissen S G, Nijenhuis L E, Engelfriet C P
J Immunogenet. 1977 Jun;4(3):167-75. doi: 10.1111/j.1744-313x.1977.tb00899.x.
Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81-4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset. In addition to B27, another HLA antigen may be associated with AS; the antigen Bw 16 was found to be significantly increased in B27 negative AS patients. HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bwel disease (IBD). In fifty-eight ulcerative colitis (UC) patients a raised incidence of A 11 was noticed. In fifty-one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty-nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly diffrent from B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD and increased frequency of Bw16 was also shown.
在118名患有强直性脊柱炎（AS）的荷兰患者中，发现81.4%的患者HLA抗原B27呈阳性。结果证明，疾病早发的患者中B27频率显著更高。除了B27之外，另一种HLA抗原可能与AS有关；在B27阴性的AS患者中发现抗原Bw16显著增加。还对109例特发性炎性肠病（IBD）患者的HLA表型频率进行了测定。在58例溃疡性结肠炎（UC）患者中，发现A11的发生率有所升高。在51例克罗恩病（CD）患者中，抗原B18的频率增加。这两种偏差均具有统计学意义。在39例同时患有AS和IBD的患者中，50%被证明B27呈阳性，这与仅患有AS的患者的B27频率有显著差异。在B27阴性的AS和IBD患者中，也显示出Bw16频率增加。
