Worwood M
Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
Clin Chim Acta. 1997 Mar 18;259(1-2):3-23. doi: 10.1016/s0009-8981(96)06488-1.
The description by Ramsay in 1957 of a practical way of determining the total iron binding capacity of serum (a measure of transferrin concentration) provided a diagnostic test for both iron deficiency and iron overload. Since 1957 the introduction of the assay for serum ferritin (in 1972) has made it possible to assess the levels of storage iron in normal subjects and assays for free erythrocyte protoporphyrin and the circulating transferrin receptor methods to evaluate iron supply for erythropoiesis. In 1957 iron metabolism in man was already well understood but its evaluation relied on measurement of tissue iron concentrations and the use of radioisotopes of iron to measure rates of erythropoiesis. The evaluation can now be carried out using the various blood assays along with the measurement of haemoglobin concentration but interpretation of the measurements in disease still requires an understanding of the way in which these measures are influenced by pathological processes.
1957年，拉姆齐描述了一种测定血清总铁结合力（一种转铁蛋白浓度的测量方法）的实用方法，为缺铁和铁过载提供了一种诊断测试。自1957年以来，血清铁蛋白检测方法（1972年引入）使得评估正常受试者的储存铁水平成为可能，同时还有游离红细胞原卟啉检测方法以及循环转铁蛋白受体方法来评估红细胞生成的铁供应。1957年时，人体铁代谢已被充分了解，但其评估依赖于组织铁浓度的测量以及使用铁的放射性同位素来测量红细胞生成速率。现在可以使用各种血液检测方法以及血红蛋白浓度测量来进行评估，但在疾病中对这些测量结果的解释仍需要了解这些测量是如何受到病理过程影响的。
