金黄色葡萄球菌中氨基糖苷类抗生素新的质粒介导的核苷酸化作用
New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.
作者信息
Le Goffic F, Martel A, Capmau M L, Baca B, Goebel P, Chardon H, Soussy C J, Duval J, Bouanchaud D H
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):258-64. doi: 10.1128/AAC.10.2.258.
Abstract
A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4'-hydroxy function of these antibiotics. The plasmid has been studied, the enzyme responsible for this resistance pattern has been isolated by affinity chromatography, and its kinetics and physicochemistry have been characterized. The target of this enzyme has also been located by demonstrating the structure of one inactivated compound, 4'-(O)-adenylyltobramycin.
摘要
已发现一株金黄色葡萄球菌野生型菌株能使多种氨基糖苷类药物（除庆大霉素成分外）失活，该菌株携带一种介导核苷酸转移酶生物合成的质粒（RAp01）。这种酶会修饰这些抗生素的4'-羟基官能团。对该质粒进行了研究，通过亲和色谱法分离出了导致这种耐药模式的酶，并对其动力学和物理化学性质进行了表征。通过确定一种失活化合物4'-(O)-腺苷基妥布霉素的结构，也确定了这种酶的作用靶点。
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本文引用的文献
1
Purification by affinity chromatography of an enzyme involved in gentamicin inactivation.通过亲和层析法纯化参与庆大霉素失活的一种酶。
FEBS Lett. 1973 Feb 1;29(3):289-291. doi: 10.1016/0014-5793(73)80041-9.
2
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus.耐药金黄色葡萄球菌对卡那霉素的灭活与磷酸化作用
Appl Microbiol. 1968 Sep;16(9):1282-4. doi: 10.1128/am.16.9.1282-1284.1968.
3
The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus.耐药病原菌的问题。金黄色葡萄球菌耐药性的染色体外性质。
Ann N Y Acad Sci. 1971 Jun 11;182:279-94. doi: 10.1111/j.1749-6632.1971.tb30664.x.
4
Transmissible multiple drug resistance in Enterobacteriaceae.肠杆菌科细菌中的可传播多重耐药性。
Science. 1972 May 19;176(4036):758-68. doi: 10.1126/science.176.4036.758.
5
Elimination by ethidium bromide of antibiotic resistance in enterobacteria and staphylococci.溴化乙锭消除肠杆菌和葡萄球菌中的抗生素抗性
J Gen Microbiol. 1968 Dec;54(3):417-25. doi: 10.1099/00221287-54-3-417.
6
Isolation and characterization of lividomycin A inactivated by Pseudomonas aeruginosa and Escherichia coli carrying R factor.
J Antibiot (Tokyo). 1972 Aug;25(8):483-4. doi: 10.7164/antibiotics.25.483.
7
3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对庆大霉素、妥布霉素和卡那霉素的3-N酶促乙酰化作用
Antimicrob Agents Chemother. 1974 Dec;6(6):680-4. doi: 10.1128/AAC.6.6.680.
8
9
Mechanisms of antibiotic resistance in bacteria.细菌中的抗生素耐药机制。
Annu Rev Biochem. 1973;42:471-506. doi: 10.1146/annurev.bi.42.070173.002351.
10
Lividomycin resistance in staphylococci by enzymatic phosphorylation.葡萄球菌中通过酶促磷酸化产生的青紫霉素耐药性。
Antimicrob Agents Chemother. 1973 Jul;4(1):1-5. doi: 10.1128/AAC.4.1.1.
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