金黄色葡萄球菌中氨基糖苷类抗生素新的质粒介导的核苷酸化作用
New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.
作者信息
Le Goffic F, Martel A, Capmau M L, Baca B, Goebel P, Chardon H, Soussy C J, Duval J, Bouanchaud D H
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):258-64. doi: 10.1128/AAC.10.2.258.
Abstract
A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4'-hydroxy function of these antibiotics. The plasmid has been studied, the enzyme responsible for this resistance pattern has been isolated by affinity chromatography, and its kinetics and physicochemistry have been characterized. The target of this enzyme has also been located by demonstrating the structure of one inactivated compound, 4'-(O)-adenylyltobramycin.
摘要
已发现一株金黄色葡萄球菌野生型菌株能使多种氨基糖苷类药物（除庆大霉素成分外）失活，该菌株携带一种介导核苷酸转移酶生物合成的质粒（RAp01）。这种酶会修饰这些抗生素的4'-羟基官能团。对该质粒进行了研究，通过亲和色谱法分离出了导致这种耐药模式的酶，并对其动力学和物理化学性质进行了表征。通过确定一种失活化合物4'-(O)-腺苷基妥布霉素的结构，也确定了这种酶的作用靶点。
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