Ohba K, Mizokami M
Second Department of Medicine, Nagoya City University Medical School.
Nihon Rinsho. 1997 Mar;55(3):540-4.
Recently, new blood-transfusion transmissible viruses, called hepatitis G virus(HGV) and GB virus-C(GBV-C), have been reported. It was found that two viruses were independent isolates of the same virus, the genomic structure resembled that of flavivirus family, and GBV-C/HGV was closely related to HCV. To elucidate the evolutionary relationship between hepatitis C virus(HCV) and GBV-C/HGV, we constructed the phylogenetic trees for the putative RNA helicase and the RNA-dependent RNA polymerase regions of the Flaviviridae by UPGMA. The tree showed that HCV was closely related to GB virus-B(GBV-B) and HGV was more nearer to GB virus-A(GBV-A) rather than HCV.
最近，已报道了新的可经输血传播的病毒，称为庚型肝炎病毒（HGV）和GB病毒C型（GBV-C）。研究发现这两种病毒是同一病毒的独立分离株，其基因组结构类似于黄病毒科，并且GBV-C/HGV与丙型肝炎病毒（HCV）密切相关。为了阐明丙型肝炎病毒（HCV）与GBV-C/HGV之间的进化关系，我们通过UPGMA构建了黄病毒科假定的RNA解旋酶和RNA依赖性RNA聚合酶区域的系统发育树。该树显示HCV与GB病毒B型（GBV-B）密切相关，而HGV与GB病毒A型（GBV-A）的关系比与HCV的关系更近。
