Sugiyama S, Koyama S, Yamaguchi T, Ikeya T, Hara H, Hashimoto Y, Morita Y, Tsuda M, Misaki T, Matsui K, Kitagawa M
Dept. of Surgery I, Toyama Medical and Pharmaceutical University.
Gan To Kagaku Ryoho. 1997 Mar;24(5):605-8.
The patient, a 48-year old male, was seen with hoarseness in December 1990. A chest radiograph and chest CT scan showed an anterior mediastinal mass. Median sternotomy revealed epithelial thymoma with involved partial lung and pericardium. After surgery, he received external radiation to the mediastinum. One year later he was given another 40 Gy external radiation in the cervical and mediastinal recurrence region. In May 1994, a chest CT scan revealed an extrapleural and bilateral lung mass. Histological examination revealed recurrent epithelial thymoma in the left cervical muscle biopsy, so treatment with cyclophosphamide and prednisolone were begun. A dose of 100 mg/body/day of cyclophosphamide and a dose of 10 mg/body/day of prednisolone were administered every 2 week. Complete remission was induced with four cycles of this treatment of cyclophosphamide and prednisolone. The chemotherapy was thus continued for 20 cycles in 14 months. This chemotherapy with cyclophosphamide and prednisolone appeared to be useful and safe for recurrent thymoma at the outpatient clinic level.
该患者为一名48岁男性，于1990年12月因声音嘶哑前来就诊。胸部X线片和胸部CT扫描显示前纵隔有一肿块。正中开胸手术显示为上皮样胸腺瘤，累及部分肺和心包。术后，他接受了纵隔外照射。一年后，他在颈部和纵隔复发区域又接受了40 Gy的外照射。1994年5月，胸部CT扫描显示胸膜外及双侧肺部有肿块。组织学检查显示左颈部肌肉活检为复发性上皮样胸腺瘤，于是开始使用环磷酰胺和泼尼松龙进行治疗。每2周给予一次剂量为100 mg/体/天的环磷酰胺和剂量为10 mg/体/天的泼尼松龙。通过四个周期的环磷酰胺和泼尼松龙治疗诱导了完全缓解。因此，化疗在14个月内持续进行了20个周期。在门诊水平上，这种环磷酰胺和泼尼松龙化疗对复发性胸腺瘤似乎是有效且安全的。
