新型半合成棘白菌素LY-303366对念珠菌属、新生隐球菌、皮炎芽生菌及曲霉属的全身感染分离株的体外活性
In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species.
作者信息
Zhanel G G, Karlowsky J A, Harding G A, Balko T V, Zelenitsky S A, Friesen M, Kabani A, Turik M, Hoban D J
机构信息
Department of Medical Microbiology and Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada.
出版信息
Antimicrob Agents Chemother. 1997 Apr;41(4):863-5. doi: 10.1128/AAC.41.4.863.
The in vitro activities of LY-303366, a new semisynthetic echinocandin, and comparators amphotericin B, 5-fluorocytosine, fluconazole, and ketoconazole against 205 systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species were determined. LY-303366 had MICs of < or = 0.32 microg/ml for all Candida albicans (n = 99), Candida glabrata (n = 18), and Candida tropicalis (n = 10) isolates tested. LY-303366 was also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 microg/ml) (n = 20), was less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 microg/ml) (n = 10), and was inactive against C. neoformans (MIC90, >10.24 microg/ml) (n = 15) and B. dermatitidis (MIC90, 16 microg/ml) (n = 29).
测定了新型半合成棘白菌素LY-303366以及两性霉素B、5-氟胞嘧啶、氟康唑和酮康唑对205株念珠菌属、新型隐球菌、皮炎芽生菌和曲霉菌属的全身分离株的体外活性。对于所有测试的白色念珠菌（n = 99）、光滑念珠菌（n = 18）和热带念珠菌（n = 10）分离株，LY-303366的最低抑菌浓度（MIC）≤0.32微克/毫升。LY-303366对曲霉菌属也有活性（90%分离株被抑制时的最低有效浓度，0.02微克/毫升）（n = 20），对近平滑念珠菌活性较低（90%分离株被抑制时的MIC [MIC90]，5.12微克/毫升）（n = 10），对新型隐球菌（MIC90，>10.24微克/毫升）（n = 15）和皮炎芽生菌（MIC90，16微克/毫升）（n = 29）无活性。
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