脂肽类抗真菌药西洛芬净对临床分离真菌的体外评价。
Evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens.
作者信息
Hanson L H, Stevens D A
机构信息
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1391-2. doi: 10.1128/AAC.33.8.1391.
Abstract
Cilofungin (LY121019) is a new lipopeptide antifungal drug. We tested this drug against 141 pathogenic fungal isolates. All fungal species were tested by broth dilution at 35 degrees C. Malassezia furfur was tested by agar dilution. The results demonstrate the specificity of cilofungin activity. Candida albicans, Candida tropicalis, and Malassezia pachydermatis were highly susceptible, whereas Candida parapsilosis, Candida pseudotropicalis, Candida krusei, Torulopsis glabrata, Blastomyces dermatitidis, Cryptococcus neoformans, Aspergillus species, M. furfur, and Paracoccidioides brasiliensis were more resistant.
摘要
西洛芬净（LY121019）是一种新型脂肽类抗真菌药物。我们用该药物对141株致病性真菌分离株进行了测试。所有真菌种类均在35摄氏度下通过肉汤稀释法进行测试。糠秕马拉色菌通过琼脂稀释法进行测试。结果证明了西洛芬净活性的特异性。白色念珠菌、热带念珠菌和厚皮马拉色菌高度敏感，而近平滑念珠菌、假热带念珠菌、克柔念珠菌、光滑念珠菌、皮炎芽生菌、新型隐球菌、曲霉菌属、糠秕马拉色菌和巴西副球孢子菌则更具抗性。
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