脂肽类抗真菌药西洛芬净对临床分离真菌的体外评价。
Evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens.
作者信息
Hanson L H, Stevens D A
机构信息
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1391-2. doi: 10.1128/AAC.33.8.1391.
Abstract
Cilofungin (LY121019) is a new lipopeptide antifungal drug. We tested this drug against 141 pathogenic fungal isolates. All fungal species were tested by broth dilution at 35 degrees C. Malassezia furfur was tested by agar dilution. The results demonstrate the specificity of cilofungin activity. Candida albicans, Candida tropicalis, and Malassezia pachydermatis were highly susceptible, whereas Candida parapsilosis, Candida pseudotropicalis, Candida krusei, Torulopsis glabrata, Blastomyces dermatitidis, Cryptococcus neoformans, Aspergillus species, M. furfur, and Paracoccidioides brasiliensis were more resistant.
摘要
西洛芬净（LY121019）是一种新型脂肽类抗真菌药物。我们用该药物对141株致病性真菌分离株进行了测试。所有真菌种类均在35摄氏度下通过肉汤稀释法进行测试。糠秕马拉色菌通过琼脂稀释法进行测试。结果证明了西洛芬净活性的特异性。白色念珠菌、热带念珠菌和厚皮马拉色菌高度敏感，而近平滑念珠菌、假热带念珠菌、克柔念珠菌、光滑念珠菌、皮炎芽生菌、新型隐球菌、曲霉菌属、糠秕马拉色菌和巴西副球孢子菌则更具抗性。
相似文献
1
Evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens.脂肽类抗真菌药西洛芬净对临床分离真菌的体外评价。
Antimicrob Agents Chemother. 1989 Aug;33(8):1391-2. doi: 10.1128/AAC.33.8.1391.
2
In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species.新型半合成棘白菌素LY-303366对念珠菌属、新生隐球菌、皮炎芽生菌及曲霉属的全身感染分离株的体外活性
Antimicrob Agents Chemother. 1997 Apr;41(4):863-5. doi: 10.1128/AAC.41.4.863.
3
In-vitro activity of cilofungin (LY121019) in comparison with amphotericin B.西洛芬净（LY121019）与两性霉素B的体外活性比较。
J Antimicrob Chemother. 1989 Sep;24(3):325-31. doi: 10.1093/jac/24.3.325.
4
Cilofungin (LY121019), an antifungal agent with specific activity against Candida albicans and Candida tropicalis.西洛芬净（LY121019），一种对白色念珠菌和热带念珠菌具有特异性活性的抗真菌剂。
Antimicrob Agents Chemother. 1988 Sep;32(9):1331-5. doi: 10.1128/AAC.32.9.1331.
5
Susceptibility of Candida species to cilofungin (LY-121019).
Mycoses. 1989 Jun;32(6):316-8. doi: 10.1111/j.1439-0507.1989.tb02251.x.
6
In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of Candida species.单独使用西洛芬净以及与其他抗真菌药物联合使用对念珠菌属临床分离株的体外比较。
Eur J Clin Microbiol Infect Dis. 1991 Jul;10(7):588-92. doi: 10.1007/BF01967280.
7
Isavuconazole, micafungin, and 8 comparator antifungal agents' susceptibility profiles for common and uncommon opportunistic fungi collected in 2013: temporal analysis of antifungal drug resistance using CLSI species-specific clinical breakpoints and proposed epidemiological cutoff values.2013年收集的常见和罕见机会性真菌对艾沙康唑、米卡芬净及8种对照抗真菌药物的敏感性概况：使用临床和实验室标准协会（CLSI）特定菌种临床断点及建议的流行病学截断值对抗真菌药物耐药性进行的时间分析
Diagn Microbiol Infect Dis. 2015 Aug;82(4):303-13. doi: 10.1016/j.diagmicrobio.2015.04.008. Epub 2015 Apr 29.
8
In vitro antifungal activity of a novel lipopeptide antifungal agent, FK463, against various fungal pathogens.新型脂肽抗真菌剂FK463对多种真菌病原体的体外抗真菌活性。
J Antibiot (Tokyo). 2000 Oct;53(10):1175-81. doi: 10.7164/antibiotics.53.1175.
9
Agar disk diffusion susceptibility tests with cilofungin (LY 121019).
J Med Vet Mycol. 1991;29(2):93-8. doi: 10.1080/02681219180000161.
10
Comparative activity in vitro of cilofungin (LY 121019) with other agents used for treatment of deep-seated Candida infections.
Mycoses. 1989 Mar;32(3):145-50. doi: 10.1111/j.1439-0507.1989.tb02223.x.
引用本文的文献
1
In vitro synergy of caspofungin and itraconazole against Aspergillus spp.: MIC versus minimal effective concentration end points.卡泊芬净与伊曲康唑对曲霉属的体外协同作用：最低抑菌浓度与最低有效浓度终点
Antimicrob Agents Chemother. 2003 Apr;47(4):1416-8. doi: 10.1128/AAC.47.4.1416-1418.2003.
2
Correlation between antifungal susceptibilities of Coccidioides immitis in vitro and antifungal treatment with caspofungin in a mouse model.体外粗球孢子菌抗真菌药敏与卡泊芬净在小鼠模型中抗真菌治疗的相关性
Antimicrob Agents Chemother. 2001 Jun;45(6):1854-9. doi: 10.1128/AAC.45.6.1854-1859.2001.
3
Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.西洛芬净与两性霉素B治疗小鼠念珠菌病的比较。
Antimicrob Agents Chemother. 1990 Aug;34(8):1619-21. doi: 10.1128/AAC.34.8.1619.
4
Comparative effects of cilofungin and amphotericin B on experimental murine candidiasis.西洛芬净和两性霉素B对实验性小鼠念珠菌病的比较作用
Antimicrob Agents Chemother. 1990 May;34(5):746-50. doi: 10.1128/AAC.34.5.746.
5
Synergy between cilofungin and amphotericin B in a murine model of candidiasis.西洛芬净与两性霉素B在小鼠念珠菌病模型中的协同作用。
Antimicrob Agents Chemother. 1991 Jul;35(7):1334-7. doi: 10.1128/AAC.35.7.1334.
6
Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis.西洛芬净单独及与两性霉素B联合应用于播散性曲霉病小鼠模型的疗效
Antimicrob Agents Chemother. 1991 Jul;35(7):1329-33. doi: 10.1128/AAC.35.7.1329.
7
W-1 solubilization and kinetics of inhibition by cilofungin of Candida albicans (1,3)-beta-D-glucan synthase.W-1对白色念珠菌（1,3）-β-D-葡聚糖合酶的溶解作用及西洛芬净的抑制动力学
Antimicrob Agents Chemother. 1991 Jan;35(1):99-103. doi: 10.1128/AAC.35.1.99.
8
Comparison of antifungal activity of amphotericin B deoxycholate suspension with that of amphotericin B cholesteryl sulfate colloidal dispersion.两性霉素B脱氧胆酸盐混悬液与两性霉素B胆固醇硫酸酯胶体分散液抗真菌活性的比较。
Antimicrob Agents Chemother. 1992 Feb;36(2):486-8. doi: 10.1128/AAC.36.2.486.
9
Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.持续静脉输注西洛芬净治疗兔实验性播散性念珠菌病的疗效。
Antimicrob Agents Chemother. 1992 Jan;36(1):56-8. doi: 10.1128/AAC.36.1.56.
10
Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis.两性霉素B胶体分散体与两性霉素B脱氧胆酸盐混悬液治疗小鼠播散性隐球菌病的疗效和安全性比较
Antimicrob Agents Chemother. 1992 Dec;36(12):2656-60. doi: 10.1128/AAC.36.12.2656.
本文引用的文献
1
Growth of Paracoccidioides brasiliensis yeast phase in a chemically defined culture medium.巴西副球孢子菌酵母相在化学成分明确的培养基中的生长
J Clin Microbiol. 1980 Aug;12(2):279-81. doi: 10.1128/jcm.12.2.279-281.1980.
2
Lysis of growing yeast-form cells of Candida albicans by echinocandin: a cytological study.棘白菌素对白色念珠菌生长中的酵母型细胞的溶解作用：一项细胞学研究。
Sabouraudia. 1981 Jun;19(2):97-110.
3
In vitro and in vivo anti-Candida activity and toxicology of LY121019.LY121019的体外和体内抗念珠菌活性及毒理学
J Antibiot (Tokyo). 1984 Sep;37(9):1054-65. doi: 10.7164/antibiotics.37.1054.
4
Obfuscation of the activity of antifungal antimicrobics by culture media.培养基对抗真菌抗菌剂活性的干扰。
J Infect Dis. 1972 Oct;126(4):353-61. doi: 10.1093/infdis/126.4.353.
5
Initial experience in therapy for progressive mycoses with itraconazole, the first clinically studied triazole.
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S77-86. doi: 10.1093/clinids/9.supplement_1.s77.
6
Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.酵母的药敏试验：一种与接种量无关的比浊法技术。
Antimicrob Agents Chemother. 1976 Oct;10(4):721-8. doi: 10.1128/AAC.10.4.721.
Zotero 插件