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In vitro kill curves of a new semisynthetic echinocandin, LY-303366, against fluconazole-sensitive and -resistant Candida species.新型半合成棘白菌素LY-303366对氟康唑敏感及耐药念珠菌属的体外杀菌曲线
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In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species.新型半合成棘白菌素LY-303366对念珠菌属、新生隐球菌、皮炎芽生菌及曲霉属的全身感染分离株的体外活性
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Antifungal dynamics of LY 303366, an investigational echinocandin B analog, against Candida ssp.LY 303366（一种研究中的棘白菌素B类似物）对念珠菌属的抗真菌动力学
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新型半合成棘白菌素LY-303366对氟康唑敏感及耐药念珠菌属的体外杀菌曲线

In vitro kill curves of a new semisynthetic echinocandin, LY-303366, against fluconazole-sensitive and -resistant Candida species.

作者信息

Karlowsky J A, Harding G A, Zelenitsky S A, Hoban D J, Kabani A, Balko T V, Turik M, Zhanel G G

机构信息

Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada.

出版信息

Antimicrob Agents Chemother. 1997 Nov;41(11):2576-8. doi: 10.1128/AAC.41.11.2576.

DOI:10.1128/AAC.41.11.2576
PMID:9371373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164168/
Abstract

In vitro killing by a new semisynthetic echinocandin, LY-303366, was characterized using clinical isolates of fluconazole-sensitive (Y58) and -resistant (Y180) Candida albicans as well as Candida glabrata (Y7) and Candida krusei (Y171). The 24-h kill curves for Y58 and Y180 demonstrated dose-independent killing of between 1 and 2 log10 with LY-303366 at concentrations of 0.1, 1, 10, 50, 100, and 1,000 times the MIC. Regrowth did not occur at 24 h with either C. albicans isolate at the aforementioned LY-303366 concentrations. At their MICs, LY-303366 and amphotericin B produced similar killing kinetics in cultures of Y58, Y180, Y7, and Y171, while all cultures exposed to fluconazole at its MIC demonstrated stasis or growth over 24 h.

摘要

使用氟康唑敏感（Y58）和耐药（Y180）的白色念珠菌临床分离株以及光滑念珠菌（Y7）和克柔念珠菌（Y171），对一种新型半合成棘白菌素LY - 303366的体外杀菌特性进行了研究。Y58和Y180的24小时杀菌曲线表明，在LY - 303366浓度为MIC的0.1、1、10、50、100和1000倍时，杀菌效果为1至2个对数级，且与剂量无关。在上述LY - 303366浓度下，两种白色念珠菌分离株在24小时均未出现再生长。在Y58、Y180、Y7和Y171的培养物中，LY - 303366和两性霉素B在其MIC时产生相似的杀菌动力学，而所有暴露于氟康唑MIC的培养物在24小时内均表现为生长停滞或生长。