Tiku M L, Makhdoomi G M, Beutner K R, Nath N, Ogra P L
J Pediatr. 1977 Oct;91(4):540-4. doi: 10.1016/s0022-3476(77)80498-8.
Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HBeAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HBeAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HBe activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HBsAg positive subjects with anti HBe did not eventually become seronegative for HBsAg.
对几组收容机构中的对象、有无症状乙肝病毒感染血清学证据的志愿献血者以及急性乙型病毒性肝炎患者进行了研究，在两到三年的时间里按顺序检测乙肝e抗原和抗体的存在情况。在9.5%的收容机构居民和志愿献血者以及24%的急性乙型病毒性肝炎患者中检测到了乙肝e抗原。乙肝e抗原阳性的对象血清中丙酮酸谷氨酸转氨酶水平常常持续升高。在26%至32%的乙肝表面抗原阳性对象中观察到了抗乙肝e活性。长期随访表明，具有抗乙肝e的乙肝表面抗原阳性对象最终并未出现乙肝表面抗原血清学转阴。
