病态赌博中多巴胺功能的改变。
Altered dopamine function in pathological gambling.
作者信息
Bergh C, Eklund T, Södersten P, Nordin C
机构信息
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge, Sweden.
出版信息
Psychol Med. 1997 Mar;27(2):473-5. doi: 10.1017/s0033291796003789.
BACKGROUND
The possibility that monoaminergic neurotransmission is altered in pathological gambling was examined.
METHODS
Monoamines and their metabolites were measured in CSF obtained at level L4-5 from ten pathological gamblers and seven controls.
RESULTS
A decrease in dopamine and an increase in 3,4-dihydroxyphenylacetic acid and homovanilic acid was found. Noradrenaline and its metabolite 3-methoxy-4-hydroxyphenylglycol was also increased but 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged.
CONCLUSION
It is suggested that the function of the dopaminergic system, possibly mediating positive and negative reward, and the noradrenergic system, possibly mediating selective attention, is changed in pathological gambling.
背景
研究了病理性赌博中是否存在单胺能神经传递改变的可能性。
方法
在L4 - 5水平采集了10名病理性赌博者和7名对照者的脑脊液，测量其中的单胺及其代谢产物。
结果
发现多巴胺减少，3,4 - 二羟基苯乙酸和高香草酸增加。去甲肾上腺素及其代谢产物3 - 甲氧基 - 4 - 羟基苯乙二醇也增加，但5 - 羟色胺和5 - 羟吲哚乙酸未改变。
结论
提示在病理性赌博中，可能介导正负性奖赏的多巴胺能系统以及可能介导选择性注意的去甲肾上腺素能系统的功能发生了改变。
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