Wrenger E, Pirsch J D, Cangro C B, D'Alessandro A M, Knechtle S J, Kalayoglu M, Sollinger H W
Department of Medicine, University of Wisconsin Hospital and Clinics, Madison 53792-7375, USA.
Transpl Int. 1997;10(2):152-6. doi: 10.1007/s001470050031.
Between 1980 and 1995, 13 patients with end-stage renal disease due to Wegener's granulomatosis received 14 renal transplants (10 cadaveric, 4 living related). The mean follow-up in the 13 successfully transplanted patients was 50 months (4-107 months). One patient had primary nonfunction and received another graft 4 months later. Three episodes of acute rejection occurred in two patients, and one of these patients lost her graft due to severe vascular rejection 4 months after transplantation. Two patients died with well-functioning grafts (one of metastatic cancer and one of sepsis). One patient presented with perisinusitis and had a mild recurrence of Wegener's disease. None of the patients developed recurrent disease in the transplanted organ. At the last follow-up, the mean creatinine (+/-SD) in the 12 patients with functioning grafts was 1.6 +/- 0.6 mgdl. We conclude that renal transplantation is an excellent treatment for renal failure due to Wegener's granulomatosis. Recurrence of the disease is uncommon in patients under immunosuppression, but careful monitoring is extremely important.
1980年至1995年间，13例因韦格纳肉芽肿导致终末期肾病的患者接受了14次肾移植（10例尸体供肾，4例亲属活体供肾）。13例移植成功患者的平均随访时间为50个月（4 - 107个月）。1例患者出现原发性移植肾功能丧失，并于4个月后接受了再次移植。2例患者发生了3次急性排斥反应，其中1例患者在移植后4个月因严重血管排斥反应而失去了移植肾。2例患者在移植肾功能良好的情况下死亡（1例死于转移性癌症，1例死于败血症）。1例患者出现鼻窦周围炎，韦格纳病有轻度复发。所有患者的移植器官均未发生疾病复发。在最后一次随访时，12例移植肾功能良好患者的平均肌酐（±标准差）为1.6±0.6mg/dl。我们得出结论，肾移植是治疗韦格纳肉芽肿所致肾衰竭的一种极佳方法。在免疫抑制患者中，疾病复发并不常见，但仔细监测极为重要。
