硝基麝香在体外人淋巴细胞微核试验及人肝癌细胞系Hep G2中的遗传毒性。

Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2.

作者信息

Kevekordes S, Zaulig A, Dunkelberg H

机构信息

Medical Institute for General Hygiene and Environmental Health, University of Göttingen, FRG.

出版信息

Toxicol Lett. 1997 Mar 14;91(1):13-7. doi: 10.1016/s0378-4274(96)03860-x.

DOI:10.1016/s0378-4274(96)03860-x

PMID:9096281

Abstract

The nitro musk compounds musk xylene (1-tert.-butyl-3,5-dimethyl-2,4,6-trinitrobenzene), musk ketone (4-tert.-butyl-3,5-dinitro-2,6-dimethylacetophenone), musk ambrette (1-tert.-butyl-4-methyl-6-methoxy-3,5-dinitrobenzene), musk moskene (1,1,3,3,5-pentamethyl-4,6-dinitroindane) and musk tibetene (1-tert.-butyl-3,4,5-trimethyl-2,6-dinitrobenzene) were tested for their genotoxic activity in the micronucleus test (MN) with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Compound concentrations were employed up to cytotoxic doses. Musk xylene, musk ketone, musk ambrette, musk moskene and musk tibetene revealed no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2.

摘要

对硝基麝香化合物二甲苯麝香（1-叔丁基-3,5-二甲基-2,4,6-三硝基苯）、酮麝香（4-叔丁基-3,5-二硝基-2,6-二甲基苯乙酮）、葵子麝香（1-叔丁基-4-甲基-6-甲氧基-3,5-二硝基苯）、西藏麝香（1,1,3,3,5-五甲基-4,6-二硝基茚满）和吐纳麝香（1-叔丁基-3,4,5-三甲基-2,6-二硝基苯）进行了体外人淋巴细胞微核试验（MN）和人肝癌细胞系Hep G2中的遗传毒性活性测试。化合物浓度使用至细胞毒性剂量。二甲苯麝香、酮麝香、葵子麝香、西藏麝香和吐纳麝香在人淋巴细胞和人肝癌细胞系Hep G2的微核试验中均未显示出遗传毒性。