Whitley R J, Kimberlin D W
Department of Pediatrics, University of Alabama at Birmingham, USA.
Clin Perinatol. 1997 Mar;24(1):267-83.
Over the past 15 years, successful antiviral therapy of herpes simplex virus (HSV) infection has emerged with safe therapeutics. Despite the major impact of acyclovir on the severity of HSV infection, morbidity and mortality from neonatal herpes exist. The development of therapeutics that impact on the natural history of HIV and AIDS just now are being realized, nearly a decade after the first beneficial effects of therapy were reported. Early investigations of antiviral agents in pregnant women and children must occur more promptly as the field of antiviral therapy advances. Improved therapeutics are likely to emerge over the next decade for both pregnant women and their offspring.
在过去15年中，已出现了安全的治疗方法用于单纯疱疹病毒（HSV）感染的成功抗病毒治疗。尽管阿昔洛韦对HSV感染的严重程度有重大影响，但新生儿疱疹仍存在发病和死亡情况。在报道了治疗的首个有益效果近十年后，目前才开始实现对HIV和艾滋病自然病程有影响的治疗方法的开发。随着抗病毒治疗领域的进展，必须更迅速地对孕妇和儿童进行抗病毒药物的早期研究。在未来十年中，很可能会出现针对孕妇及其后代的改进治疗方法。
