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抗巨细胞病毒（抗CMV）免疫球蛋白G亲和力在识别有传播先天性CMV感染风险的孕妇中的作用。

Anticytomegalovirus (anti-CMV) immunoglobulin G avidity in identification of pregnant women at risk of transmitting congenital CMV infection.

作者信息

Lazzarotto T, Spezzacatena P, Varani S, Gabrielli L, Pradelli P, Guerra B, Landini M P

机构信息

Department of Clinical and Experimental Medicine, Section of Microbiology, Medical School, University of Bologna, Bologna, Italy.

出版信息

Clin Diagn Lab Immunol. 1999 Jan;6(1):127-9. doi: 10.1128/CDLI.6.1.127-129.1999.

DOI:10.1128/CDLI.6.1.127-129.1999
PMID:9874675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC95671/
Abstract

In this work, we show that the determination of the anticytomegalovirus antibody avidity carried out before week 18 of gestation is a helpful tool to identify women for enrollment in prenatal diagnosis. This procedure can identify all pregnant women who will give birth to an infected newborn.

摘要

在本研究中，我们表明，在妊娠18周前进行抗巨细胞病毒抗体亲和力测定是一种有助于确定纳入产前诊断的孕妇的工具。该程序可以识别所有将分娩出受感染新生儿的孕妇。

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本文引用的文献

1
Prenatal diagnosis of congenital cytomegalovirus infection.先天性巨细胞病毒感染的产前诊断
J Clin Microbiol. 1998 Dec;36(12):3540-4. doi: 10.1128/JCM.36.12.3540-3544.1998.
2
Avidity of immunoglobulin G directed against human cytomegalovirus during primary and secondary infections in immunocompetent and immunocompromised subjects.免疫功能正常和免疫功能低下受试者在原发性和继发性感染期间针对人巨细胞病毒的免疫球蛋白G亲和力
Clin Diagn Lab Immunol. 1997 Jul;4(4):469-73. doi: 10.1128/cdli.4.4.469-473.1997.
3
Treatment of viral infections during pregnancy and the neonatal period.孕期及新生儿期病毒感染的治疗。
Clin Perinatol. 1997 Mar;24(1):267-83.
4
Value of cytomegalovirus (CMV) IgG avidity index for the diagnosis of primary CMV infection in pregnant women.巨细胞病毒（CMV）IgG亲和力指数在诊断孕妇原发性巨细胞病毒感染中的价值。
J Infect Dis. 1997 Apr;175(4):944-6. doi: 10.1086/513996.
5
Evaluation of virological procedures to detect fetal human cytomegalovirus infection: avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum.检测胎儿人巨细胞病毒感染的病毒学方法评估：IgG抗体亲和力、羊水和母血清中的病毒检测
J Med Virol. 1996 Sep;50(1):9-15. doi: 10.1002/(SICI)1096-9071(199609)50:1<9::AID-JMV3>3.0.CO;2-5.
6
IgM antibody detection of ppUL80A and ppUL32 by immunoblotting: an early parameter for recurrent cytomegalovirus infection in renal transplant recipients.通过免疫印迹法检测ppUL80A和ppUL32的IgM抗体：肾移植受者复发性巨细胞病毒感染的早期指标
J Med Virol. 1996 Mar;48(3):289-94. doi: 10.1002/(SICI)1096-9071(199603)48:3<289::AID-JMV13>3.0.CO;2-8.
7
Polymerase chain reaction for prenatal diagnosis of congenital human cytomegalovirus infection.用于先天性人巨细胞病毒感染产前诊断的聚合酶链反应
J Med Virol. 1995 Dec;47(4):462-6. doi: 10.1002/jmv.1890470428.
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Maturation of antibody avidity after primary human cytomegalovirus infection is delayed in immunosuppressed solid organ transplant patients.在免疫抑制的实体器官移植患者中，原发性人巨细胞病毒感染后抗体亲和力的成熟会延迟。
J Med Virol. 1994 Dec;44(4):317-22. doi: 10.1002/jmv.1890440402.
9
Accuracy of amniotic fluid testing before 21 weeks' gestation in prenatal diagnosis of congenital cytomegalovirus infection.
Prenat Diagn. 1994 Nov;14(11):1055-9. doi: 10.1002/pd.1970141108.
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Congenital cytomegalovirus infection: The relative importance of primary and recurrent maternal infection.先天性巨细胞病毒感染：母体原发性感染和复发性感染的相对重要性
N Engl J Med. 1982 Apr 22;306(16):945-9. doi: 10.1056/NEJM198204223061601.