Georgopoulos K
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.
Curr Opin Immunol. 1997 Apr;9(2):222-7. doi: 10.1016/s0952-7915(97)80139-2.
Intimate interactions between multipotential hemopoietic stem cells and their microenvironment work towards redefining the identity and the differentiative fate of these primitive cells. Molecular cues delivered by the microenvironment frequently act in an instructive fashion by initiating intracellular signaling pathways that ultimately target a select group of transcription factors. These transcriptional regulators in turn trigger a cascade of genetic changes that ultimately determine the course of the cells during differentiation. Gene inactivation studies on the PU.1, Ikaros and GATA-3 genes have revealed that their encoded factors are essential for the earliest commitment step into the B and T lymphoid lineages.
多能造血干细胞与其微环境之间的密切相互作用致力于重新定义这些原始细胞的特性和分化命运。微环境传递的分子信号通常以一种指导性方式发挥作用，通过启动细胞内信号通路，最终作用于一组特定的转录因子。这些转录调节因子进而引发一系列基因变化，最终决定细胞在分化过程中的走向。对PU.1、Ikaros和GATA-3基因的基因失活研究表明，它们编码的因子对于最早向B和T淋巴细胞谱系的定向分化步骤至关重要。
