Kumar P V, Owji S M, Talei A R, Malekhusseini S A
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Iran.
Acta Cytol. 1997 Mar-Apr;41(2):364-8. doi: 10.1159/000332526.
To determine the role of fine needle aspiration cytology in the diagnosis of extramedullary plasmacytoma.
The study group consisted of 13 patients with palpable masses at various sites. The tumors were aspirated for cytologic study.
The smears revealed groups of mature and immature plasma cells at various stages of maturation. Mature plasma cells showed an eccentric nucleus and abundant, deep, basophilic cytoplasm with a paranuclear halo. Plasmablasts (immature plasma cells) showed a prominent, eccentric nucleus with single, large nucleolus and abundant, deep, basophilic cytoplasm with no paranuclear halo. Binucleate and multinucleate forms were also seen quite often. The tumors were excised, and the histologic sections confirmed the cytologic diagnosis. All the patients received radiotherapy. One patient (18 years old) developed recurrence and died due to extensive infiltration into the maxilla and mandible. Two patients (57 and 62 years) developed multiple myeloma one to two years after the excision of tumors, and both died two to three months later. The remaining 10 patients were alive and well at this writing.
The smears from all 13 patients were diagnosed as extramedullary plasmacytomas by fine needle aspiration cytology.
确定细针穿刺细胞学检查在髓外浆细胞瘤诊断中的作用。
研究组由13例在不同部位可触及肿块的患者组成。对肿瘤进行穿刺以进行细胞学研究。
涂片显示处于不同成熟阶段的成熟和未成熟浆细胞群。成熟浆细胞显示偏位核以及丰富、深染的嗜碱性胞质，伴有核旁晕。原始浆细胞（未成熟浆细胞）显示突出的偏位核，有单个大核仁，以及丰富、深染的嗜碱性胞质，无核旁晕。双核和多核形式也很常见。肿瘤被切除，组织学切片证实了细胞学诊断。所有患者均接受了放疗。1例患者（18岁）复发，因广泛浸润上颌骨和下颌骨而死亡。2例患者（57岁和62岁）在肿瘤切除后1至2年发生多发性骨髓瘤，均在2至3个月后死亡。在撰写本文时，其余10例患者健在。
通过细针穿刺细胞学检查，13例患者的涂片均被诊断为髓外浆细胞瘤。
