乙醇胺缩醛磷脂对铁和铜依赖性脂质过氧化的抑制作用。
Inhibitory effect of ethanolamine plasmalogen on iron- and copper-dependent lipid peroxidation.
作者信息
Zommara M, Tachibana N, Mitsui K, Nakatani N, Sakono M, Ikeda I, Imaizumi K
机构信息
Department of Food Science and Technology, School of Agriculture, Kyushu University, Fukuoka, Japan.
出版信息
Free Radic Biol Med. 1995 Mar;18(3):599-602. doi: 10.1016/0891-5849(94)00155-d.
The effect of ethanolamine plasmalogen (EtnPm) on lipid peroxidation was investigated in liposomal suspension of egg yolk phosphatidylcholine. EtnPm inhibited iron- and copper-dependent peroxidation in the presence of preformed hydroperoxides, although it was not effective for radical initiator mediated lipid peroxidation. EtnPm resulted in complete binding of iron to liposomal lipids, suggesting that EtnPm exerts its inhibitory effect on lipid peroxidation through inhibiting preformed peroxide decomposition by trapping transition metal ions.
在蛋黄卵磷脂脂质体悬浮液中研究了乙醇胺缩醛磷脂（EtnPm）对脂质过氧化的影响。在预先形成的氢过氧化物存在下，EtnPm抑制铁和铜依赖性过氧化，尽管它对自由基引发剂介导的脂质过氧化无效。EtnPm导致铁与脂质体脂质完全结合，这表明EtnPm通过捕获过渡金属离子抑制预先形成的过氧化物分解，从而对脂质过氧化发挥抑制作用。
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