Read J S, Troendle J F, Klebanoff M A
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development (NICHD), Bethesda, Md, USA.
Am J Public Health. 1997 Feb;87(2):192-8. doi: 10.2105/ajph.87.2.192.
The purpose of this study was to determine the relative importance of infectious disease as a cause of infant mortality in the United States and to identify characteristics at birth associated with subsequent infectious disease mortality.
Birth and infant death certificate data from the National Center for Health Statistics (NCHS) 1983 through 1987 Linked Birth/ Infant Death Data Sets were analyzed.
Infection was the underlying cause of death for over 16000 infants, representing the fourth leading cause of mortality in this cohort. Almost 90% of infectious disease deaths during infancy were due to noncongenital infections, and the majority of these deaths occurred during the postneonatal period. Low birthweight, preterm birth, and male gender were independently associated with postneonatal mortality due to noncongenital infection.
NCHS should revise its classification system for causes of infant mortality to incorporate an "Infectious Diseases" category. Future research should be directed toward clarifying the low birthweight-infectious disease mortality relationship and determining the degree to which infection-related infant deaths might be prevented by existing vaccines or improved access to health care.
本研究旨在确定在美国传染病作为婴儿死亡原因的相对重要性，并确定与随后的传染病死亡相关的出生时特征。
分析了国家卫生统计中心（NCHS）1983年至1987年的出生和婴儿死亡证明数据，即关联出生/婴儿死亡数据集。
感染是16000多名婴儿的潜在死亡原因，是该队列中第四大主要死因。婴儿期近90%的传染病死亡是由于非先天性感染，且这些死亡大多发生在新生儿后期。低出生体重、早产和男性性别与非先天性感染导致的新生儿后期死亡率独立相关。
国家卫生统计中心应修订其婴儿死亡原因分类系统，纳入“传染病”类别。未来的研究应致力于阐明低出生体重与传染病死亡率之间的关系，并确定现有疫苗或改善医疗服务可预防与感染相关的婴儿死亡的程度。
