Hollman P C, van Trijp J M, Mengelers M J, de Vries J H, Katan M B
DLO State Institute for Quality Control of Agricultural Products (RIKLIT-DLO), Wageningen, The Netherlands.
Cancer Lett. 1997 Mar 19;114(1-2):139-40. doi: 10.1016/s0304-3835(97)04644-2.
Quercetin, a dietary antioxidant flavonoid, has anticarcinogenic properties. We quantified the absorption of quercetin in ileostomists. Absorption was 52 +/- 5% for quercetin glucosides from onions, 17 +/- 15% for quercetin rutinoside, and 24 +/- 9% for quercetin aglycone. The plasma quercetin concentration in subjects with an intact colon, after ingestion of fried onions, apples and pure quercetin rutinoside, decreased slowly with elimination half-lives of about 25 h. Thus, repeated dietary intake of quercetin will lead to accumulation in plasma. The relative bioavailability of quercetin from apples and rutinoside was one-third of that from onions. Absorption kinetics and bioavailibility might be determined by the type of glycoside. Dietary quercetin could increase the antioxidant capacity of blood plasma.
槲皮素是一种膳食抗氧化类黄酮，具有抗癌特性。我们对回肠造口者体内槲皮素的吸收情况进行了量化。洋葱中槲皮素糖苷的吸收率为52±5%，芦丁槲皮素为17±15%，槲皮素苷元为24±9%。在摄入炒洋葱、苹果和纯芦丁槲皮素后，结肠完整的受试者体内血浆槲皮素浓度缓慢下降，消除半衰期约为25小时。因此，重复从饮食中摄入槲皮素会导致其在血浆中蓄积。苹果和芦丁槲皮素中槲皮素的相对生物利用度是洋葱中槲皮素的三分之一。吸收动力学和生物利用度可能由糖苷类型决定。膳食中的槲皮素可提高血浆的抗氧化能力。
