Lutgendorf S K, Antoni M H, Ironson G, Klimas N, Kumar M, Starr K, McCabe P, Cleven K, Fletcher M A, Schneiderman N
Department of Psychology, University of Miami, Coral Gables, Florida 33124-2070, USA.
J Consult Clin Psychol. 1997 Feb;65(1):31-43. doi: 10.1037//0022-006x.65.1.31.
This study tested the effects of a 10-week group cognitive-behavioral stress management (CBSM) intervention on mood and immunologic parameters in HIV-seropositive gay men whose disease had progressed to a symptomatic stage. Men were randomized to either CBSM or a modified waiting-list control group. The CBSM intervention significantly decreased self-reported dysphoria, anxiety, and total distress. Individuals who practiced relaxation more consistently had significantly greater drops in dysphoria. The intervention also decreased herpes simplex virus-Type 2 (HSV-2) immunoglobulin G antibody titers. The control group showed no significant changes in either mood or antibody titers. Individual difference analyses revealed that decreases in dysphoria significantly predicted lower HSV-2 antibody titers by the end of the 10-week period. Neither group displayed changes in HSV-Type 1 antibody titers or in CD4+ or CD8+ cell numbers.
本研究测试了为期10周的团体认知行为压力管理（CBSM）干预对疾病已进展至症状期的HIV血清阳性男同性恋者情绪和免疫参数的影响。男性被随机分为CBSM组或改良候补对照组。CBSM干预显著降低了自我报告的烦躁不安、焦虑和总体痛苦。更持续练习放松的个体烦躁不安的下降幅度显著更大。该干预还降低了2型单纯疱疹病毒（HSV-2）免疫球蛋白G抗体滴度。对照组在情绪或抗体滴度方面均无显著变化。个体差异分析显示，在10周结束时，烦躁不安的降低显著预测了较低的HSV-2抗体滴度。两组在1型疱疹病毒抗体滴度或CD4+或CD8+细胞数量方面均未显示出变化。
