Ellis D A, Tan A K
Department of Otolaryngology, University of Toronto, Ontario.
J Otolaryngol. 1997 Apr;26(2):92-6.
This study was conducted to evaluate the cosmetic use of botulinum toxin type A (Botox), which blocks the release of acetylcholine at the presynaptic neuromuscular junction leading to an irreversible, but temporary chemical denervation muscular paralysis and weakness. This produces a significant cosmetic improvement of wrinkling in the upper face due to hyperfunctional animation.
A prospective clinical study representing our experience with this new technique is presented. Patient selection and evaluation, classification of animation lines, techniques, results and complications are discussed. In a 15-month period, 23 patients with seven anatomic sites were injected. Twenty-three patients had the lateral aspect and the inferior aspect of their squint lines injected, and 26 patients had their glabellar frownlines injected.
Significant improvement occurred to the average depth and length of the glabellar frownlines. The subjective improvement by the patients was also significant. Regarding the crow's feet, the lateral canthal lines showed more improvement than the inferior lateral canthal lines because the latter has a greater component of zygomaticus major and minor muscle, which contributes to the inferior lateral squint line.
Botox is a safe, easy-to-use, effective modality for the temporary elimination of hyperfunctioning upper-facial muscles.
本研究旨在评估A型肉毒杆菌毒素（保妥适）的美容用途，该毒素可阻断突触前神经肌肉接头处乙酰胆碱的释放，导致不可逆但暂时的化学性去神经肌肉麻痹和无力。这可显著改善因功能亢进性面部活动导致的上脸皱纹。
介绍一项前瞻性临床研究，展示我们在这项新技术方面的经验。讨论了患者选择与评估、面部活动纹分类、技术、结果及并发症。在15个月期间，对23例患者的7个解剖部位进行了注射。23例患者的斜视纹外侧和下方进行了注射，26例患者的眉间皱眉纹进行了注射。
眉间皱眉纹的平均深度和长度有显著改善。患者的主观改善也很显著。关于鱼尾纹，外眦纹比外眦下纹改善更明显，因为后者有更大比例的颧大肌和颧小肌成分，这导致了外眦下斜视纹。
保妥适是一种安全、易用、有效的方式，可暂时消除功能亢进的上脸肌肉。
