细小病毒B19 DNA在患有和未患慢性关节病的年轻患者滑膜中的持续存在情况。
Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy.
作者信息
Söderlund M, von Essen R, Haapasaari J, Kiistala U, Kiviluoto O, Hedman K
机构信息
Department of Virology, Haartman Institute, University of Helsinki, Finland.
出版信息
Lancet. 1997 Apr 12;349(9058):1063-5. doi: 10.1016/S0140-6736(96)09110-6.
BACKGROUND
Human parvovirus B19 replicates in erythroid precursors of the bone marrow, and several diseases have been attributed to this virus including some cases of juvenile chronic arthropathy.
METHODS
Tissue samples from children with juvenile arthritis and from healthy young adults with recent joint trauma were examined for B19 DNA by PCR. We also studied the timing of the parvovirus infection serologically.
FINDINGS
All samples of synovial fluid, bone marrow, and blood were negative for B19 DNA. Eight (28%) of the 29 children with chronic arthritis had B19 DNA in synovial tissues. However, an even higher proportion of the non-arthropathy controls were positive for B19 DNA in synovial membranes (13 [48%] of 27). All the individuals with B19 DNA in synovial membrane had serum IgG antibodies to B19.
INTERPRETATION
Genomic B19 DNA can persist in the synovial membranes not only in patients with chronic arthropathy but also in healthy immunocompetent individuals. The diagnostic criteria for parvovirus arthropathy must be reevaluated.
背景
人细小病毒B19在骨髓的红系前体细胞中复制，该病毒与多种疾病有关，包括一些青少年慢性关节炎病例。
方法
采用聚合酶链反应（PCR）检测青少年关节炎患儿及近期有关节创伤的健康年轻成人的组织样本中的B19 DNA。我们还通过血清学方法研究了细小病毒感染的时间。
结果
所有滑膜液、骨髓和血液样本的B19 DNA检测均为阴性。29例慢性关节炎患儿中有8例（28%）滑膜组织中存在B19 DNA。然而，滑膜组织中B19 DNA阳性的非关节炎对照组比例更高（27例中有13例[48%]）。所有滑膜组织中存在B19 DNA的个体血清中均有抗B19 IgG抗体。
解读
基因组B19 DNA不仅可在慢性关节炎患者的滑膜组织中持续存在，也可在免疫功能正常的健康个体中持续存在。细小病毒关节炎的诊断标准必须重新评估。
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